After 18 years of failed IVF attempts, a couple has become pregnant thanks to Columbia University’s STAR system—an AI-powered breakthrough that identified three hidden sperm in an azoospermic sample, marking a historic first in fertility medicine. (Source: Image by RR)

Future Applications May Include Widespread Use in Fertility Centers Nationwide

After 18 years of failed attempts to conceive, a couple has finally achieved pregnancy thanks to a pioneering AI system that uncovered what human eyes could not: three viable sperm cells in a semen sample from a man diagnosed with azoospermia—a rare condition where no sperm are typically detected. Developed at the Columbia University Fertility Center, the new technology, called the STAR method (Sperm Tracking and Recovery), uses AI-powered imaging to scan millions of microscopic visuals in under an hour, identifying hidden sperm with unprecedented precision. The couple is now expecting their first child in December, marking the first known successful pregnancy resulting from this technology.

The STAR method, as reported in cnn.com, represents a major breakthrough in addressing male infertility, which accounts for up to 40% of infertility cases. Historically, men with azoospermia faced limited and invasive options such as testicular biopsies or were left with the option of using donor sperm. Dr. Zev Williams, who led the STAR system’s development, emphasized the life-changing impact of the technology. In one striking example, a sample declared sperm-free after two days of manual searching was re-analyzed by STAR, which located 44 sperm in under an hour. The system’s strength lies not only in its speed but in its gentle, non-destructive approach—preserving fragile sperm for use in IVF.

The STAR platform is part of a broader wave of AI applications transforming fertility care. From analyzing embryo viability to tailoring IVF medication protocols, AI is increasingly helping clinicians make smarter, faster, and more compassionate decisions. Experts like Dr. Aimee Eyvazzadeh have praised AI for its ability to “help us see what our eyes can’t,” amplifying—not replacing—human expertise. However, others remain cautious. Dr. Gianpiero Palermo, a pioneer in assisted fertilization, acknowledged the promise of STAR but warned that AI tools must be rigorously validated to avoid raising false hopes, especially in cases where no viable sperm exist.

Despite the caution, STAR’s debut signals a transformative moment in reproductive medicine. While the technology is currently only available at Columbia, its success may open doors for patients worldwide who once believed biological parenthood was out of reach. With a cost of under $3,000, STAR could soon become a more accessible option in fertility clinics across the U.S. and beyond. As AI continues to revolutionize how we diagnose and treat infertility, the fusion of advanced algorithms with compassionate care may help solve one of humanity’s oldest and most emotionally charged challenges.

read more at cnn.com